BackExplain differences between whole-genome sequencing (WGS) and whole-exome sequencing (WES), and describe advantages and disadvantages of each approach for identifying disease-causing mutations in a genome. Which approach was used for the Human Genome Project?
The human genome project discovered that protein coding regions make up what percent of the human genome?
Transgenic organisms are organisms that contain what?
The purpose of human gene therapy is to what?
Using the data Table B, calculate the average number of kilobase (kb) pairs per centimorgan in the six multicellular eukaryotic organisms. How would this information influence strategies to clone genes known only by a mutant phenotype in these organisms?
Diagram the mechanism by which CRISPR–Cas functions in the immune system of bacteria and archaea.
Describe how CRISPR–Cas has been modified to create a genome-editing tool.
Describe three major goals of the Human Genome Project.
Describe the human genome in terms of genome size, the percentage of the genome that codes for proteins, how much is composed of repetitive sequences, and how many genes it contains. Describe two other features of the human genome.
The Human Genome Project has demonstrated that in humans of all races and nationalities approximately 99.9 percent of the genome sequence is the same, yet different individuals can be identified by DNA fingerprinting techniques. What is one primary variation in the human genome that can be used to distinguish different individuals? Briefly explain your answer.
Through the Human Genome Project (HGP), a relatively accurate human genome sequence was published from combined samples from multiple individuals. It serves as a reference for a haploid genome. How do results from personal genome projects (PGP) differ from those of the HGP?