15. Genomes and Genomics
Comparative Genomics
04:55
Practice this topic
- Multiple Choice
Two similar genes that arose from a gene duplication and are found in the same organism are called what?
- Multiple Choice
Synteny describes conservation of what?
- Open Question
The genetic difference between two Drosophila species, D. heteroneura and D. silvestris, as measured by nucleotide diversity, is about 1.8 percent. The difference between chimpanzees (Pan troglodytes) and humans (H. sapiens) is about the same, yet the latter species is classified in a different genera. In your opinion, is this valid? Explain why.
- Open Question
How do comparisons between genomes of related species help refine gene annotation?
- Open QuestionYou have cloned the mouse ortholog (see Genetic Analysis 14.2 for definition) of the gene associated with human Huntington disease (HD) and wish to examine its expression in mice. Outline the approaches you might take to examine the temporal and spatial expression pattern at the cellular level.
- Open Question
Annotation involves identifying genes and gene-regulatory sequences in a genome. List and describe characteristics of a genome that are hallmarks for identifying genes in an unknown sequence. What characteristics would you look for in a bacterial genome? A eukaryotic genome?