2. Mendel's Laws of Inheritance

Pedigrees

Open Question
Below is a partial pedigree of hemophilia in the British Royal Family descended from Queen Victoria, who is believed to be the original 'carrier' in this pedigree. Analyze the pedigree and indicate which females are also certain to be carriers. What is the probability that Princess Irene is a carrier?
Open Question
The accompanying pedigree shows the transmission of albinism (absence of skin pigment) in a human family.

The female I-1 and her mate, male I-2, had four children, one of whom has albinism. What is the probability that they could have had a total of four children with any other outcome except one child with albinism and three with normal pigmentation?
Multiple Choice
This pedigree exhibits which of the following inheritance patterns?
Multiple Choice
This pedigree exhibits which of the following inheritance patterns?
Multiple Choice
This pedigree exhibits which of the following inheritance patterns?
Open Question
In this chapter, we focused on the Mendelian postulates, probability, and pedigree analysis. We also considered some of the methods and reasoning by which these ideas, concepts, and techniques were developed. On the basis of these discussions, what answers would you propose to the following questions:How do we know whether an organism expressing a dominant trait is homozygous or heterozygous?
Open Question
In this chapter, we focused on the Mendelian postulates, probability, and pedigree analysis. We also considered some of the methods and reasoning by which these ideas, concepts, and techniques were developed. On the basis of these discussions, what answers would you propose to the following questions:Since experimental crosses are not performed in humans, how do we know how traits are inherited?
Open Question
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.

The probability that the son of a woman with an autosomal recessive condition is a heterozygous carrier
Open Question
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.

The person receiving genetic counseling
Open Question
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.

The probability that the healthy brother of a woman with an autosomal recessive condition is a heterozygous carrier
Open Question
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.

A person who on the basis of family history must be a heterozygous carrier of a recessive mutant allele
Open Question
Match each statement (a–e) with the best answer from the following list: consultand, 50%, prior probability, 66.7%, obligate carrier, 100%.

The Mendelian risk that a person is a heterozygous carrier of a recessive condition
Open Question
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).
Open Question
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)A normal male and an albino female have six children, three normal and three albino.
Open Question
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.)A normal male and an albino female have six children, all normal.