Multiple Choice
Which type of pattern recognition receptor when bound to MAMPs triggers the formation of the inflammasome?
19. Innate Immunity
Pattern Recognition Receptors (PRRs)
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Which of the following is not considered a MAMP (Microbe/Pathogen-Associated Molecular Pattern)?
A
Carbohydrates on microbial surfaces.
B
Peptidoglycan from gram + bacteria.
C
Damaged host cell DNA.
D
Lipopolysaccharide (LPS).
Verified step by step guidance1
Understand the concept of MAMPs: Microbe/Pathogen-Associated Molecular Patterns (MAMPs) are molecules associated with groups of pathogens that are recognized by cells of the innate immune system.
Identify common examples of MAMPs: These include structures like lipopolysaccharides (LPS) found in the outer membrane of gram-negative bacteria, peptidoglycan found in the cell walls of gram-positive bacteria, and certain carbohydrates on microbial surfaces.
Analyze the options given: Carbohydrates on microbial surfaces, peptidoglycan from gram-positive bacteria, and lipopolysaccharide (LPS) are all typical MAMPs.
Consider the nature of damaged host cell DNA: Damaged host cell DNA is not a microbial structure but rather a host-derived molecule, which is not typically recognized as a MAMP.
Conclude which option is not a MAMP: Based on the analysis, damaged host cell DNA does not fit the definition of a MAMP, as it is not a microbial pattern but rather a host-derived signal.
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