Table of contents

1. Introduction to Microbiology3h 22m
2. Disproving Spontaneous Generation1h 18m
3. Chemical Principles of Microbiology3h 38m
4. Water1h 28m
5. Molecules of Microbiology2h 23m
6. Cell Membrane & Transport3h 28m
7. Prokaryotic Cell Structures & Functions5h 52m
8. Eukaryotic Cell Structures & Functions2h 18m
9. Microscopes2h 46m
10. Dynamics of Microbial Growth4h 36m
11. Controlling Microbial Growth4h 10m
12. Microbial Metabolism5h 16m
13. Photosynthesis2h 31m
14. DNA Replication2h 25m
15. Central Dogma & Gene Regulation7h 14m
16. Microbial Genetics4h 44m
17. Biotechnology3h 0m
18. Viruses, Viroids, & Prions4h 56m
19. Innate Immunity7h 15m
20. Adaptive Immunity7h 14m
21. Principles of Disease6h 57m

20. Adaptive Immunity

Clonal Selection

Microbiology

20. Adaptive Immunity

Clonal Selection

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Multiple Choice

All of the following are postulates of the clonal selection theory EXCEPT:

Each B lymphocyte bears a single type of receptor with a unique specificity.

BCR occupation is required for cell activation.

Differentiated cells derived from an activated B lymphocyte bear receptors of similar specificity as the parent cell.

B lymphocytes bearing receptors for self-molecules are destroyed at an early stage.

All are postulates of the clonal selection theory.

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Verified step by step guidance

Understand the clonal selection theory: It explains how B lymphocytes (B cells) are selected for activation and proliferation based on their ability to bind to specific antigens.

Identify the key postulates of the clonal selection theory: Each B cell has a unique receptor specificity, receptor occupation is necessary for activation, and activated B cells produce progeny with the same specificity.

Recognize the exception: The destruction of B cells bearing receptors for self-molecules is a process known as clonal deletion, which is part of immune tolerance, not clonal selection.

Differentiate between clonal selection and clonal deletion: Clonal selection involves the activation and proliferation of B cells with receptors for foreign antigens, while clonal deletion involves the removal of self-reactive B cells.

Conclude that the statement about the destruction of self-reactive B cells is not a postulate of the clonal selection theory, but rather a mechanism of maintaining self-tolerance.