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Multiple Choice
Which of the following is NOT an organ where clonal selection occurs?
A
Spleen.
B
Lymph nodes.
C
Bone marrow.
D
Mucosa associated lymphoid tissue.
Verified step by step guidance
1
Understand the concept of clonal selection: Clonal selection is a process in the immune system where specific B or T lymphocytes are selected for proliferation based on their ability to bind to an antigen. This process primarily occurs in secondary lymphoid organs.
Identify the primary and secondary lymphoid organs: Primary lymphoid organs include the bone marrow and thymus, where lymphocytes are generated and mature. Secondary lymphoid organs include the spleen, lymph nodes, and mucosa-associated lymphoid tissue (MALT), where clonal selection typically occurs.
Analyze the options given: The options provided are spleen, lymph nodes, bone marrow, and mucosa-associated lymphoid tissue.
Determine where clonal selection occurs: Clonal selection occurs in secondary lymphoid organs such as the spleen, lymph nodes, and MALT. These are sites where mature lymphocytes encounter antigens and undergo clonal expansion.
Identify the organ that does not fit: Bone marrow is a primary lymphoid organ where lymphocytes are produced and mature, but it is not a site for clonal selection. Therefore, bone marrow is the correct answer as it is not an organ where clonal selection occurs.