17. The Blood

Which of the following is not an anticlotting agent produced by endothelial cells?

a. Prostacyclin

b. Protein C

c. Antithrombin-III

d. Warfarin

Tissue plasminogen activator, urokinase, and plasmin are important components of:

a. coagulation.

b. fibrinolysis.

c. platelet plug formation.

d. hemostasis.

The anticoagulant drug warfarin primarily disrupts the extrinsic/tissue factor coagulation pathway. Explain why disrupting only this pathway disrupts the entire coagulation cascade.

Cirrhosis of the liver often reduces production of many types of plasma proteins, including albumin and clotting factors. Predict the effects on the body of decreased numbers of these proteins in the plasma. Would this also affect the number of γ-globulins in the plasma? Why or why not?

Elise is a 36-year-old woman who has volunteered to donate red bone marrow to a patient in need of a bone marrow transplant for aplastic anemia. The physician performing the bone marrow extraction is an intern, and it is her first time doing the procedure. She asks that you prepare a site on Elise's tibia for the procedure. Is this a good place for red bone marrow to be extracted, considering Elise's age? Why or why not? Can you suggest an alternative location? Explain.