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Multiple Choice
Which of the following is NOT a function of regulatory T cells?
A
Regulatory T cells contain receptors that remove cytokines required for the growth and proliferation of effector cells.
B
Regulatory T cells induce apoptosis of effector cells via perforin and granzyme.
C
Regulatory T cells secret cytokines that reduce the signaling activity of effector T cells.
D
Regulatory T cells interact with MHC class I APCs and inhibit their maturation.
Verified step by step guidance
1
Understand the role of regulatory T cells (Tregs) in the immune system. They are crucial for maintaining immune tolerance and preventing autoimmune diseases by suppressing the activation and proliferation of other immune cells.
Review the mechanisms by which regulatory T cells exert their suppressive functions. These include the secretion of inhibitory cytokines, direct cell-to-cell contact, and modulation of antigen-presenting cells (APCs).
Examine the options provided in the problem. Identify which functions are typically associated with regulatory T cells. For example, Tregs are known to secrete cytokines like IL-10 and TGF-beta to suppress effector T cell activity.
Consider the interaction of regulatory T cells with APCs. Regulatory T cells usually interact with MHC class II molecules on APCs, not MHC class I, which is primarily involved in presenting antigens to cytotoxic T cells.
Identify the statement that does not align with the known functions of regulatory T cells. In this case, the interaction with MHC class I APCs and inhibition of their maturation is not a recognized function of regulatory T cells.