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Multiple Choice
What does it mean when TReg cells control lymphocyte functions via peripheral tolerance?
A
TReg cells show T and B lymphocytes in the peripheral lymphoid organs which antigens to attack.
B
TReg cells inhibit T and B lymphocytes that have exited the primary lymphoid organs from attacking self-antigens.
C
TReg cells control the production of T and B lymphocytes and ensure only cells with immune tolerance proliferate.
D
TReg cells inhibit T and B lymphocytes that are maturing within the primary lymphoid organs.
Verified step by step guidance
1
Understand the role of TReg cells: TReg cells, or regulatory T cells, are crucial for maintaining immune system balance and preventing autoimmune responses. They help in controlling the activity of other immune cells, such as T and B lymphocytes.
Define peripheral tolerance: Peripheral tolerance refers to the mechanisms that prevent immune cells from attacking the body's own tissues after they have matured and left the primary lymphoid organs. This is essential for preventing autoimmune diseases.
Identify the location of action: TReg cells exert their influence in peripheral lymphoid organs, where mature lymphocytes reside after leaving primary lymphoid organs like the thymus and bone marrow.
Clarify the function of TReg cells in peripheral tolerance: TReg cells inhibit the activity of T and B lymphocytes that have exited the primary lymphoid organs, ensuring they do not attack self-antigens, which are the body's own proteins and cells.
Distinguish between primary and peripheral tolerance: Primary tolerance occurs during the maturation of lymphocytes within primary lymphoid organs, while peripheral tolerance involves the regulation of mature lymphocytes in peripheral lymphoid organs by TReg cells.