Table of contents

1. Introduction to Microbiology3h 22m
2. Disproving Spontaneous Generation1h 18m
3. Chemical Principles of Microbiology3h 38m
4. Water1h 28m
5. Molecules of Microbiology2h 23m
6. Cell Membrane & Transport3h 28m
7. Prokaryotic Cell Structures & Functions5h 52m
8. Eukaryotic Cell Structures & Functions2h 18m
9. Microscopes2h 46m
10. Dynamics of Microbial Growth4h 36m
11. Controlling Microbial Growth4h 10m
12. Microbial Metabolism5h 16m
13. Photosynthesis2h 31m
14. DNA Replication2h 25m
15. Central Dogma & Gene Regulation7h 14m
16. Microbial Genetics4h 44m
17. Biotechnology3h 0m
18. Viruses, Viroids, & Prions4h 56m
19. Innate Immunity7h 15m
20. Adaptive Immunity7h 14m
21. Principles of Disease6h 57m

14. DNA Replication

Introduction to DNA Replication

Microbiology

14. DNA Replication

Introduction to DNA Replication

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Multiple Choice

Which of the following is incorrect regarding DNA replication forks?

DNA replication forks begin forming at the origin of replication (ORI).

DNA replication forks are caused by helicase separating two complementary strands of DNA.

There are two replication forks found in each replicating prokaryotic chromosome.

DNA replication forks are found at both ends of the replication 'bubble'.

None of the above are incorrect.

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Verified step by step guidance

Understand the concept of a DNA replication fork: A DNA replication fork is a structure that forms within the nucleus during DNA replication. It is created by helicases, which break the hydrogen bonds holding the two DNA strands together, allowing each strand to be copied.

Identify the origin of replication (ORI): The ORI is a specific sequence in the genome where replication begins. In prokaryotes, there is typically a single ORI, while eukaryotes have multiple ORIs.

Examine the role of helicase: Helicase is an enzyme that unwinds the DNA double helix, creating two single strands that serve as templates for replication. This action forms the replication fork.

Consider the number of replication forks in prokaryotic chromosomes: In prokaryotic cells, such as bacteria, the circular DNA typically has two replication forks that move in opposite directions from the ORI, eventually meeting at the opposite side of the circle.

Understand the replication 'bubble': As the DNA unwinds, a replication 'bubble' forms, with replication forks at each end. This bubble expands as replication proceeds, allowing the entire DNA molecule to be replicated.