The poison curare (kyoo-RAH-ray) blocks the binding of acetylcholine to its receptors at the neuromuscular junction. What effects would you predict from such a poison? Can you think of any useful applications for it? Why might an overdose of it be lethal?
14. The Autonomic Nervous System
Neurotransmitters of the ANS
- Open Question
- Open Question
Match the following neurotransmitters with their correct description.
_____GABA
_____Dopamine
_____Substance P
_____Acetylcholine
_____Glutamate
_____Endorphins
_____Norepinephrine
a. Neuropeptide involved in transmission of pain
b. Neurotransmitter released at the neuromuscular junction
c. Major excitatory neurotransmitter in the brain
d. Major inhibitory neurotransmitter in the brain
e. Neuropeptide involved in relief of pain
f. Catecholamine involved in the autonomic nervous system
g. Catecholamine involved in movement and behavior
- Open Question
Which neurotransmitter(s) is/are used by sympathetic postganglionic neurons?
a. Epinephrine
b. Norepinephrine
c. Acetylcholine
d. Both a and b
e. All of the above
- Open Question
Many chemical warfare agents, such as the poisonous gas sarin, block the enzyme acetylcholinesterase in the synaptic cleft. What effects will this poison have on muscle contraction? (Connects to Chapter 10) What effects will it have on the autonomic nervous system? What symptoms would you expect to see from this poison?
- Open QuestionMrs. Jones has had a progressive decline in her mental capabilities in the last five or six years. At first her family attributed her occasional memory lapses, confusion, and agitation to grief over her husband's death six years earlier. When examined, Mrs. Jones was aware of her cognitive problems and was shown to have an IQ score approximately 30 points less than would be predicted by her work history. A CT scan showed diffuse cerebral atrophy. The physician prescribed an acetylcholinesterase inhibitor and Mrs. Jones showed slight improvement. What is Mrs. Jones's problem? Why did the acetylcholinesterase inhibitor help?