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Multiple Choice
Which of the following is NOT a component of TCRs?
A
Alpha chain.
B
CD3 complex.
C
Constant & Variable Regions.
D
Beta chain.
E
None of the above.
Verified step by step guidance
1
Understand the structure of T-cell receptors (TCRs), which are crucial for the immune response. TCRs are composed of two different polypeptide chains, typically an alpha and a beta chain, each having constant and variable regions.
Recognize that the alpha and beta chains of TCRs are similar to the light and heavy chains of antibodies, with variable regions responsible for antigen recognition.
Identify the role of the CD3 complex, which is not a part of the TCR itself but is associated with it. The CD3 complex is essential for signal transduction once the TCR binds to an antigen.
Differentiate between components that are intrinsic to the TCR structure (alpha and beta chains, constant and variable regions) and those that are associated but not part of the TCR structure (CD3 complex).
Conclude that the CD3 complex, while associated with TCRs, is not a structural component of the TCR itself, making it the correct answer to the question.