Table of contents

1. Introduction to Microbiology3h 22m
2. Disproving Spontaneous Generation1h 18m
3. Chemical Principles of Microbiology3h 38m
4. Water1h 28m
5. Molecules of Microbiology2h 23m
6. Cell Membrane & Transport3h 28m
7. Prokaryotic Cell Structures & Functions5h 52m
8. Eukaryotic Cell Structures & Functions2h 18m
9. Microscopes2h 46m
10. Dynamics of Microbial Growth4h 36m
11. Controlling Microbial Growth4h 10m
12. Microbial Metabolism5h 16m
13. Photosynthesis2h 31m
14. DNA Replication2h 25m
15. Central Dogma & Gene Regulation7h 14m
16. Microbial Genetics4h 44m
17. Biotechnology3h 0m
18. Viruses, Viroids, & Prions4h 56m
19. Innate Immunity7h 15m
20. Adaptive Immunity7h 14m
21. Principles of Disease6h 57m

16. Microbial Genetics

DNA Repair Mechanisms

Microbiology

16. Microbial Genetics

DNA Repair Mechanisms

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Multiple Choice

What is the function of DNA glycosylase during base excision repair?

Addition of the correct nucleotide.

Cleavage of the phosphodiester bond.

Addition of the correct nucleobase.

Removal of the incorrect nucleotide.

Removal of the incorrect nucleobase.

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Verified step by step guidance

Understand the context of base excision repair (BER), which is a cellular mechanism that repairs damaged DNA throughout the cell cycle. It is primarily responsible for removing small, non-helix-distorting base lesions from the genome.

Identify the role of DNA glycosylase in the BER pathway. DNA glycosylases are a family of enzymes involved in the first step of base excision repair.

Recognize that DNA glycosylases are responsible for identifying and removing damaged or incorrect bases from DNA. They do this by cleaving the N-glycosidic bond between the base and the sugar-phosphate backbone, leaving an abasic site.

Clarify that the removal of the incorrect nucleobase by DNA glycosylase is crucial because it initiates the repair process, allowing other enzymes to further process the abasic site and restore the correct DNA sequence.

Conclude that the specific function of DNA glycosylase during base excision repair is the removal of the incorrect nucleobase, which is the first and essential step in correcting DNA damage.