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Multiple Choice
How are natural killer cells able to kill infected host cells?
A
NK cells bind to IgG antibodies on the infected cell's surface and send apoptosis signals to the infected cell.
B
NK cells send perforin and protease granules to the infected cell triggering apoptosis of the infected cell.
C
NK cells bind to antigens on the infected cell's surface and send signals triggering apoptosis of the infected cell.
D
NK cells mark infected cells for destruction and the infected cell will later be destroyed by cytotoxic t cells.
E
A and B.
F
C and D.
G
D only.
H
All of the above.
Verified step by step guidance
1
Understand the role of natural killer (NK) cells: NK cells are a type of lymphocyte in the immune system that play a crucial role in the host-rejection of both tumors and virally infected cells.
Identify the mechanisms by which NK cells induce apoptosis: NK cells can induce apoptosis in infected cells through the release of cytotoxic granules containing perforin and granzymes, which are proteases that trigger cell death.
Examine the role of antibodies: NK cells can recognize infected cells through antibody-dependent cellular cytotoxicity (ADCC), where they bind to IgG antibodies that are attached to antigens on the surface of infected cells.
Consider the interaction with other immune cells: NK cells can also interact with other immune cells, such as cytotoxic T cells, to enhance the immune response against infected cells.
Evaluate the options given: Analyze each option to determine which mechanisms are described and whether they align with the known functions of NK cells, focusing on the correct combination of mechanisms that NK cells use to kill infected host cells.