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Multiple Choice
A goiter may form because __________.
A
the thyroid cannot release T3 and T4 so the hormones build up in the gland
B
low blood levels of T3 and T4 inhibit the negative feedback loop and an overload of TRH causes enlargement of the gland
C
there is too much iodine in the diet
D
of none of the listed reasons
E
low blood levels of T3 and T4 inhibit the negative feedback loop and an overload of TSH causes enlargement of the gland
Verified step by step guidance
1
Understand the role of the thyroid gland: The thyroid gland produces hormones T3 (triiodothyronine) and T4 (thyroxine), which are crucial for regulating metabolism, growth, and development.
Learn about the negative feedback loop: Normally, when levels of T3 and T4 are sufficient, they inhibit the release of TRH (thyrotropin-releasing hormone) from the hypothalamus and TSH (thyroid-stimulating hormone) from the pituitary gland, maintaining hormone balance.
Identify the cause of goiter formation: A goiter can form when there is a disruption in this feedback loop, such as low levels of T3 and T4, which fail to inhibit TRH and TSH release, leading to excessive stimulation of the thyroid gland.
Recognize the effect of TSH overload: When TSH levels are high due to low T3 and T4, it causes the thyroid gland to enlarge as it attempts to produce more hormones, resulting in a goiter.
Clarify the correct answer: The correct reason for goiter formation in this context is low blood levels of T3 and T4, which inhibit the negative feedback loop, causing an overload of TSH and enlargement of the gland.