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Multiple Choice
ATPgammaS is a form of ATP that cannot be hydrolyzed by enzymes. If this compound were introduced to cells so that it replaced the normal ATP present in the cell, which of the following would you predict?
A
An increase in the numbers of phosphorylated proteins in the cell
B
An increase in anabolic cellular reactions
C
An increase in cell division
D
Two of the listed responses would be expected.
E
A decrease in phosphorylated proteins in the cell
Verified step by step guidance
1
Understand the role of ATP in cellular processes: ATP (adenosine triphosphate) is the primary energy carrier in cells. It provides energy for various cellular activities, including phosphorylation of proteins, which is crucial for signal transduction and regulation of cellular activities.
Recognize the significance of ATP hydrolysis: ATP is hydrolyzed to ADP (adenosine diphosphate) and an inorganic phosphate, releasing energy that is used for cellular processes. This hydrolysis is essential for the phosphorylation of proteins.
Identify the properties of ATPgammaS: ATPgammaS is a non-hydrolyzable analog of ATP. It means that enzymes cannot break it down to release energy or phosphate groups, which are necessary for phosphorylation.
Predict the impact of ATPgammaS on protein phosphorylation: Since ATPgammaS cannot be hydrolyzed, it cannot donate a phosphate group to proteins. Therefore, the number of phosphorylated proteins in the cell would decrease because the phosphorylation process is hindered.
Conclude the effects on cellular processes: With a decrease in phosphorylated proteins, cellular processes that depend on phosphorylation, such as signal transduction and regulation of metabolic pathways, would be disrupted. This would not lead to an increase in anabolic reactions or cell division, but rather a decrease in these activities.