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Multiple Choice
People with Kartagener's syndrome suffer from a variety of ailments, including the intriguing condition known as situs inversus, a reversal of the abdominal and thoracic organs. This condition occurs because of __________.
A
a defect in immotile cilia that causes them to be motile
B
mutations that disrupt monocilia function
C
defective Sonic hedgehog gene
D
none of the listed reasons
E
a defect in motile cilia that renders them immotile
Verified step by step guidance
1
Understand the role of cilia in embryonic development. Cilia are hair-like structures that play a crucial role in the movement of fluids and signaling during development.
Recognize that Kartagener's syndrome is associated with immotile cilia. This condition is part of a group of disorders known as primary ciliary dyskinesia, where cilia are unable to move properly.
Learn about situs inversus, a condition where the positions of the internal organs are mirrored from their normal arrangement. This occurs due to disruptions in the normal left-right asymmetry during embryonic development.
Identify that motile cilia are responsible for establishing left-right asymmetry in the developing embryo. When these cilia are immotile, they fail to create the necessary fluid flow that determines organ positioning.
Conclude that the correct answer is a defect in motile cilia that renders them immotile, leading to conditions like situs inversus in Kartagener's syndrome.