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Multiple Choice
Which of the following best describes the experimental evidence that the FOXP2 gene is vital to the normal development of vocalization in vertebrates and yet has evolved among different vertebrate lineages?
A
Replacing the FOXP2 gene in mice with the human form of the gene had a neutral effect on development of vocalization in mice.
B
Knocking out one of the two FOXP2 genes in mice and humans had no effect on the development of vocalization in either species.
C
Replacing the mouse FOXP2 gene with songbird versions of the gene caused the transgenic mice to vocalize like songbirds.
D
When scientists knocked out the FOXP2 gene in human subjects, they observed the development of severe speech and language impairment.
E
Replacing the FOXP2 gene in mice with a humanized version of the gene had no negative effects on the mice but did lead to the development of brain cells in neural circuits that are associated with speech development in humans.
Verified step by step guidance
1
Begin by understanding the role of the FOXP2 gene. It is known to be involved in the development of speech and language in humans and vocalization in other vertebrates.
Consider the experimental evidence provided in the options. Each option describes a different experiment involving the FOXP2 gene in mice or humans.
Evaluate the first option: Replacing the FOXP2 gene in mice with the human form of the gene had a neutral effect on development of vocalization in mice. This suggests that the human version of the gene does not disrupt normal vocalization in mice.
Examine the second option: Knocking out one of the two FOXP2 genes in mice and humans had no effect on the development of vocalization in either species. This implies that the presence of one functional FOXP2 gene is sufficient for normal vocalization.
Analyze the correct answer: Replacing the FOXP2 gene in mice with a humanized version of the gene had no negative effects on the mice but did lead to the development of brain cells in neural circuits associated with speech development in humans. This indicates that the human version of FOXP2 can integrate into the mouse genome without disrupting vocalization, while also promoting neural development related to speech.