Join thousands of students who trust us to help them ace their exams!Watch the first video
Multiple Choice
If a modified form of GTP that cannot be enzymatically converted to GDP were added to a culture of cells, the likely result would be __________.
A
the inactivation of ligand-gated ion channels
B
the inactivation of G-protein-coupled signaling pathways
C
the inhibition of pathways stimulated by tyrosine-kinase receptors
D
receptor tyrosine kinases would be stimulated by the additional phosphate groups present in the modified GTP
E
that the activated G proteins would remain locked in the "on" position, transmitting signal even in the absence of a signaling molecule
Verified step by step guidance
1
Understand the role of GTP in cell signaling: GTP (guanosine triphosphate) is a molecule that binds to G-proteins, activating them. When GTP is bound, the G-protein is in an 'on' state, capable of transmitting signals inside the cell.
Recognize the normal process of GTP hydrolysis: In typical cellular signaling, GTP is hydrolyzed to GDP (guanosine diphosphate), which inactivates the G-protein, turning the signal 'off'.
Consider the effect of a non-hydrolyzable GTP analog: If a modified form of GTP that cannot be converted to GDP is introduced, the G-protein cannot be turned 'off' because the hydrolysis step is blocked.
Analyze the impact on G-protein-coupled signaling pathways: Since the G-protein remains in the 'on' state, it continuously transmits signals, even without the presence of a signaling molecule, leading to prolonged activation of downstream pathways.
Conclude the outcome: The continuous activation of G-proteins would result in the persistent transmission of signals, potentially leading to cellular responses that are independent of external signals, which could disrupt normal cellular functions.