Look over the 10 diseases approved for genetic health risk assessment listed in Application Chapter B. Select one disease other than the three discussed in Application Chapter B or in this chapter (alpha-1 antitrypsin deficiency, late-onset Alzheimer disease, and celiac disease) or another of the diseases of your choice. Do a brief Internet search to find and download (1) one article for a nonscientific audience identifying the gene or genes whose alleles are associated with occurrence of the disease and (2) one scientific paper that provides data supporting the association of specific alleles of the gene or genes with the disease. Write a short summary combining the information contained in the two papers.

Sanders 3rd Edition
Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels
Problem 13cTwo populations of deer, one of them large and living in a mainland forest and the other small and inhabiting a forest on an island, regularly exchange members that migrate across a land bridge that connects the island to the mainland. In which population do you expect to see the greatest allele frequency change? Why?
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Key Concepts
Genetic Drift
Gene Flow
Population Size and Allele Frequency Change
Two populations of deer, one of them large and living in a mainland forest and the other small and inhabiting a forest on an island, regularly exchange members that migrate across a land bridge that connects the island to the mainland. If you compared the allele frequencies in the two populations, what would you expect to find?
Two populations of deer, one of them large and living in a mainland forest and the other small and inhabiting a forest on an island, regularly exchange members that migrate across a land bridge that connects the island to the mainland. An earthquake destroys the bridge between the island and the mainland, making migration impossible for the deer. What do you expect will happen to allele frequencies in the two populations over the following 10 generations?
The mtDNA sequence of Neanderthals is more similar to that of modern humans than to that of Denisovans. However, analyses of nuclear DNA clearly indicate that Neandertals and Denisovans share a more recent common ancestor than either of these hominins shares with modern humans. Propose a hypothesis to resolve the discrepancy between the mtDNA and the nuclear genome.