Textbook Question
Explain the following processes involving chromosome mutations and cancer development.
How the chromosome mutation producing the Philadelphia chromosome leads to CML.
Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
Not the one you use?Change textbookSelect a different textbook
Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooks
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.6c
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.6cChapter 14, Problem C.6c
Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. Under what circumstances do you think radiation treatment is a good choice to treat cancer?
Verified step by step guidance1
Understand that radiation treatment works by damaging the DNA of cells, which prevents them from dividing and growing. This effect is more pronounced in rapidly dividing cells, such as cancer cells.
Consider that radiation is a good choice when the cancer is localized, meaning it is confined to a specific area and has not spread extensively to other parts of the body. This allows targeted radiation to minimize damage to healthy tissues.
Recognize that radiation is often used when surgical removal of the tumor is not possible or as an adjunct to surgery to eliminate remaining cancer cells.
Evaluate the type and stage of cancer, as some cancers are more sensitive to radiation due to their cell cycle characteristics and DNA repair capabilities.
Take into account the patient's overall health and ability to tolerate radiation, as well as the potential side effects, to determine if radiation is an appropriate treatment option.
Verified video answer for a similar problem:
This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
1mWas this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mechanism of Radiation Therapy
Radiation therapy uses high-energy radiation to damage the DNA within cancer cells, causing breaks in the DNA strands. This damage prevents the cells from dividing and leads to cell death, particularly affecting rapidly dividing cancer cells more than normal cells.
Recommended video:
Guided course
09:12
Transgenic Organisms and Gene Therapy
Cancer Cell Sensitivity and Tumor Characteristics
Radiation is most effective on tumors that are localized and composed of cells that divide rapidly. Tumors with well-defined boundaries and those that are radiosensitive respond better to radiation, making it a suitable treatment option in such cases.
Recommended video:
Guided course
09:46Cancer Characteristics
Treatment Context and Patient Factors
Radiation therapy is chosen based on factors like tumor location, size, stage, and patient health. It is often used when surgery is not feasible, to shrink tumors before surgery, or to eliminate remaining cancer cells post-surgery, balancing effectiveness with minimizing damage to healthy tissue.
Recommended video:
Guided course
08:52F Factor and Hfr
Related Practice
Textbook Question
What are the advantages and disadvantages of using insertion alleles versus alleles generated by chemicals (as in TILLING) in reverse genetic studies?
Textbook Question
You have cloned the mouse ortholog of the gene associated with human Huntington disease (HD) and wish to examine its expression in mice. Outline the approaches you might take to examine the temporal and spatial expression pattern at the cellular level.
Textbook Question
Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. Is there a risk of damage to noncancer cells?
Textbook Question
Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. How can radiation treatment control or cure cancer?
Textbook Question
Diagram the mechanism by which CRISPR–Cas functions in the immune system of bacteria and archaea.