Explain the following processes involving chromosome mutations and cancer development.
How the chromosome mutation producing Burkitt lymphoma generates the disease.

For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop.

Explain why cancer is almost certain to develop with the inheritance of one mutated copy of RB1.

Using the data in Table B, calculate the average number of kilobase (kb) pairs per centimorgan in the six multicellular eukaryotic organisms. How would this information influence strategies to clone genes known only by a mutant phenotype in these organisms?

What are community-based genetic screening programs? What is the intent of such screening programs? Why are members of specific communities or populations offered the chance to participate in such programs?

Explain the following processes involving chromosome mutations and cancer development.

How the chromosome mutation producing the Philadelphia chromosome leads to CML.

What are the advantages and disadvantages of using insertion alleles versus alleles generated by chemicals (as in TILLING) in reverse genetic studies?

You have cloned the mouse ortholog of the gene associated with human Huntington disease (HD) and wish to examine its expression in mice. Outline the approaches you might take to examine the temporal and spatial expression pattern at the cellular level.