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Multiple Choice
What two genes are often mutated in colon cancer?
A
ras and myoD
B
p21 and p53
C
BRCA1 and BRCA2
D
APC and myoD
E
ras and p53
Verified step by step guidance
1
Understand that colon cancer is often associated with mutations in specific genes that regulate cell growth and division.
Recognize that the ras gene is a proto-oncogene, which means it normally helps cells grow. When mutated, it can become an oncogene, leading to uncontrolled cell division.
Identify that the p53 gene is a tumor suppressor gene, which normally helps prevent cancer by repairing DNA or initiating apoptosis if the DNA cannot be repaired. Mutations in p53 can lead to a loss of this protective function.
Consider the options given: ras and myoD, p21 and p53, BRCA1 and BRCA2, APC and myoD. Note that myoD is involved in muscle differentiation, not typically associated with colon cancer.
Conclude that the correct pair of genes often mutated in colon cancer is ras and p53, as these are both directly involved in pathways that can lead to cancer when mutated.