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Multiple Choice
Which of the following is a mechanism by which neurotransmitters can be rapidly cleared from the synaptic cleft?
A
The neurotransmitters are actively transported back into the presynaptic cells to be repackaged into synaptic vesicles.
B
The neurotransmitters are transferred to glia to be metabolized.
C
Neurotransmitters are removed by simple diffusion.
D
Neurotransmitters are removed by enzymatic hydrolysis of the neurotransmitter.
E
All of the listed responses are correct.
Verified step by step guidance
1
Understand that neurotransmitters are chemical messengers that transmit signals across a synapse from one neuron to another neuron, muscle cell, or gland cell.
Recognize that after neurotransmitters are released into the synaptic cleft, they need to be cleared to terminate the signal and prepare the synapse for the next transmission.
Identify the mechanisms by which neurotransmitters can be cleared from the synaptic cleft: reuptake into the presynaptic neuron, uptake by glial cells, diffusion away from the synaptic cleft, and enzymatic degradation.
Reuptake involves the active transport of neurotransmitters back into the presynaptic neuron, where they can be repackaged into vesicles for future release.
Enzymatic degradation involves enzymes breaking down neurotransmitters in the synaptic cleft, rendering them inactive and unable to bind to receptors.