Multiple Choice
A nonsense mutation:
15. Gene Expression
Mutations
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Which type of mutation is least likely to affect protein function?
A
Addition of single bases
B
Insertion of three bases
C
Deletion of single bases
D
Base-pair substitution
Verified step by step guidance1
Understand the types of mutations: Mutations can be classified into several types, including base-pair substitutions, insertions, and deletions. Each type affects the DNA sequence differently.
Base-pair substitution: This involves the replacement of one nucleotide base with another. It may result in a silent mutation, where the change does not affect the amino acid sequence due to the redundancy of the genetic code.
Insertion of single bases: Adding a single base can cause a frameshift mutation, altering the reading frame of the genetic code, which can significantly affect the protein function.
Deletion of single bases: Similar to insertion, deleting a single base can also cause a frameshift mutation, leading to a potentially nonfunctional protein.
Insertion of three bases: Adding three bases does not change the reading frame, as it adds a complete codon, which is less likely to disrupt protein function compared to single base insertions or deletions.
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