Certain animal species, such as the black-footed ferret, are nearly extinct and currently exist only in captive populations. Other species, such as the panda, are also threatened but exist in the wild thanks to intensive captive breeding programs. What strategies would you suggest in the case of black-footed ferrets and in the case of pandas to monitor and minimize inbreeding depression?

The mtDNA sequence of Neanderthals is more similar to that of modern humans than to that of Denisovans. However, analyses of nuclear DNA clearly indicate that Neandertals and Denisovans share a more recent common ancestor than either of these hominins shares with modern humans. Propose a hypothesis to resolve the discrepancy between the mtDNA and the nuclear genome.

If you were to compare your genome sequence with that of your parents, how would it differ? If you were to compare your genome sequence with another student's in the class, how would it differ? What additional difference might you see if your genome was compared with that of a sub-Saharan African, or if you are of sub-Saharan African descent, with that of a non-African?

Genetic Analysis 20.1 predicts the number of individuals expected to have the blood group genotypes MM, MN, and NN. Perform a chi-square analysis using the number of people observed and expected in each blood-type category, and state whether the sample is in H-W equilibrium.

In a population of rabbits, f(C₁) = 0.70 and f(C₂) = 0.30. The alleles exhibit an incomplete dominance relationship in which C₁C₁ produces black rabbits, C₁C₂ produces tan-colored rabbits, and C₂C₂ produces rabbits with white fur. If the assumptions of the Hardy–Weinberg principle apply to the rabbit population, what are the expected frequencies of black, tan, and white rabbits?

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 8 in 100 newborn infants have SCD.

What are the frequencies of the wild-type (βᴬ) and mutant (βˢ) alleles in this population?