Textbook Question
Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell. How can radiation treatment control or cure cancer?
Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.7c
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.7cChapter 14, Problem C.7c
Based on what you read in this chapter, Can a tumor arise from a single mutated cell? Are all the cells in a tumor identical?
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Understand the concept of tumorigenesis: Tumors often originate from a single cell that has undergone mutations leading to uncontrolled cell division. This mutated cell proliferates, giving rise to a mass of cells.
Recognize that the initial mutation in one cell can cause it to divide abnormally, forming a clonal population of cells derived from that original mutated cell.
Consider that as the tumor grows, additional mutations can occur in different cells within the tumor, leading to genetic diversity among the tumor cells.
Therefore, not all cells in a tumor are identical; they can have different mutations and characteristics due to ongoing genetic changes during tumor progression.
Summarize that a tumor can indeed arise from a single mutated cell, but the cells within the tumor are typically heterogeneous because of subsequent mutations and selection.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Clonal Origin of Tumors
Tumors often arise from a single mutated cell that undergoes uncontrolled division, leading to a mass of cells with a common ancestor. This concept explains how one initial genetic alteration can initiate tumor formation.
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Cancer Characteristics
Genetic Heterogeneity in Tumors
Although tumors may start from one cell, subsequent mutations during cell division create genetic diversity among tumor cells. This heterogeneity affects tumor behavior, treatment response, and progression.
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03:45Descriptive Genetics
Mutation and Cell Proliferation
Mutations in genes regulating cell growth and division can cause cells to proliferate abnormally. Understanding how mutations disrupt normal cell cycle control is key to explaining tumor development and diversity.
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Related Practice
Textbook Question
Diagram the mechanism by which CRISPR–Cas functions in the immune system of bacteria and archaea.
Textbook Question
Why do most cancers require the mutation of multiple genes?
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Describe how CRISPR–Cas has been modified to create a genome-editing tool.
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Do you think it is important that participation in community-based genetic screening be entirely voluntary? Why or why not?
Textbook Question
The inheritance of certain mutations of BRCA1 can make it much more likely that a woman will develop breast or ovarian cancer in her lifetime. Can you say with certainty that a woman inheriting a mutation of BRCA1 will definitely develop breast or ovarian cancer in her lifetime? Why or why not?
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