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Multiple Choice
Which class of glial cells contributes most to the formation of the blood-brain barrier?
A
Neurons
B
Schwann cells
C
Radial glia
D
Ependymal cells
E
Astrocytes
Verified step by step guidance
1
Begin by understanding the role of the blood-brain barrier (BBB). The BBB is a selective permeability barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). It protects the brain from toxins and pathogens while allowing essential nutrients to pass through.
Identify the types of cells involved in the formation and maintenance of the BBB. The main cell types include endothelial cells, which form the walls of the capillaries, and glial cells, which provide support and protection for neurons.
Focus on the glial cells, as the question specifically asks about them. Glial cells in the CNS include astrocytes, oligodendrocytes, microglia, and ependymal cells. Each type has distinct functions, but astrocytes are particularly important in the context of the BBB.
Astrocytes are star-shaped glial cells that play a crucial role in the formation and maintenance of the BBB. They contribute by releasing signaling molecules that influence the tight junctions between endothelial cells, enhancing the barrier's selectivity and integrity.
Conclude by recognizing that astrocytes are the class of glial cells that contribute most significantly to the formation of the blood-brain barrier, as they interact closely with endothelial cells to regulate the permeability and protect the brain from harmful substances.