Multiple Choice
The expression of a gene located in a tightly coiled region of DNA can be promoted by __________.
16. Regulation of Expression
Eukaryotic Chromatin Modifications
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Which of the following causes transcription to be increased for a specific gene?
A
Histones in that region are deacetylated.
B
DNA is methylated in the regulatory region of the gene.
C
Histones in that region are acetylated.
D
The chromatin structure is tightly packed.
E
B and D.
Verified step by step guidance1
Understand the role of histones and chromatin structure in gene expression. Histones are proteins that help package DNA into chromatin. The structure of chromatin can influence gene expression by making DNA more or less accessible to transcription machinery.
Learn about histone acetylation. Acetylation of histones typically leads to a more relaxed chromatin structure, which allows transcription factors and RNA polymerase easier access to the DNA, thereby increasing transcription.
Contrast histone acetylation with deacetylation. Deacetylation of histones generally results in a more condensed chromatin structure, reducing access to the DNA and decreasing transcription.
Explore DNA methylation. Methylation of DNA, particularly in the regulatory regions of genes, is often associated with reduced transcription as it can inhibit the binding of transcription factors.
Evaluate the options given in the problem. The correct answer involves histone acetylation, which increases transcription by loosening the chromatin structure, making the DNA more accessible for transcription.
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