Imagine discovering a loss-of-function mutation in a eukaryotic gene. You determine the gene's nucleotide sequence from the start site for transcription to the termination point of transcription and find no differences from the wild-type sequence. Explain where you think the mutation might be and how the mutation might be acting.

If a base-pair change occurs in DNA, thisa. is a mutation.b. would be a mutation only if it falls in a protein-coding part of a gene.c. would be a mutation only if it falls in a transcribed part of the genome.d. is not a mutation, because only one base pair has been altered.

If a base-pair change occurs in DNA, thisa. is a mutation.b. would be a mutation only if it falls in a protein-coding part of a gene.c. would be a mutation only if it falls in a transcribed part of the genome.d. is not a mutation, because only one base pair has been altered.

A geneticist found that a particular mutation had no effect on the polypeptide encoded by a gene. This mutation probably involveda. deletion of one nucleotide.b. alteration of the start codon.c. insertion of one nucleotide.d. substitution of one nucleotide.

If a fragment of a chromosome breaks off and then reattaches to the original chromosome but in the reverse direction, the resulting chromosomal abnormality is calleda. a deletion.b. an inversion.c. a translocation.d. a nondisjunction.

Imagine discovering a loss-of-function mutation in a eukaryotic gene. You determine the gene's nucleotide sequence from the start site for transcription to the termination point of transcription and find no differences from the wild-type sequence. Explain where you think the mutation might be and how the mutation might be acting.

Which of the following mutations would be most likely to have a harmful effect on an organism?a. a deletion of three nucleotides near the middle of a geneb. a single nucleotide deletion in the middle of an intronc. a single nucleotide deletion near the end of the coding sequenced. a single nucleotide insertion downstream of, and close to, the start of the coding sequence