Multiple Choice
Which of the following statements correctly describes the difference between the leading and the lagging strands of DNA during DNA replication?
14. DNA Synthesis
Leading & Lagging DNA Strands
Multiple Choice
After the formation of a replication bubble, which of the following is the correct sequence of enzymes used for the synthesis of the lagging DNA strand?
A
Primase, helicase, DNA polymerase, ligase
B
Helicase, primase, ligase, DNA polymerase
C
Helicase, DNA polymerase, primase, ligase
D
Ligase, primase, DNA polymerase, helicase
E
Helicase, primase, DNA polymerase, ligase
Verified step by step guidance1
Understand the role of each enzyme involved in DNA replication: Helicase unwinds the DNA double helix, primase synthesizes RNA primers, DNA polymerase extends the DNA strand, and ligase joins Okazaki fragments.
Identify the sequence of events in the synthesis of the lagging strand: The lagging strand is synthesized discontinuously in small segments called Okazaki fragments.
Begin with helicase: Helicase unwinds the DNA, creating a replication bubble and exposing the template strand for replication.
Next, primase synthesizes short RNA primers on the lagging strand, providing a starting point for DNA polymerase.
DNA polymerase then extends the DNA strand by adding nucleotides to the RNA primer, and finally, ligase joins the Okazaki fragments to form a continuous DNA strand.
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