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Multiple Choice
Which of the following processes is the first event to take place in translation?
A
Base pairing of charged methionine-tRNA to AUG of the messenger RNA.
B
Binding of the larger ribosomal subunit to smaller ribosomal subunits.
C
The ribosome reaches a stop codon.
D
The small subunit of the ribosome recognizes and attaches to the mRNA.
Verified step by step guidance
1
Translation is the process by which ribosomes synthesize proteins using mRNA as a template. It involves several key steps, starting with initiation.
The first event in translation is the recognition and binding of the mRNA by the small ribosomal subunit. This is crucial for the ribosome to correctly position itself at the start codon of the mRNA sequence.
The small ribosomal subunit scans the mRNA from the 5' end to locate the start codon, typically AUG, which codes for methionine.
Once the start codon is identified, the charged methionine-tRNA base pairs with the AUG codon, setting the stage for the larger ribosomal subunit to join and form a complete ribosome.
After the larger ribosomal subunit binds, the ribosome is fully assembled and ready to proceed with elongation, where amino acids are added sequentially to form a polypeptide chain.