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Multiple Choice
Which of the following accurately characterizes our current understanding of cancer development?
A
Mutations in a single gene cannot significantly increase susceptibility to cancer.
B
Study results suggest that mutations in genes that are transcribed into ncRNA do not likely contribute to cancer development.
C
We now understand that all cancers result from some mutation in the p53 gene.
D
Nearly all cancers are caused by the multistep accumulation of mutations over the life span of the individual.
E
In order for a cell to become fully cancerous, it typically must have at least one active oncogene and the mutation or loss of several tumor-suppressor genes.
Verified step by step guidance
1
Understand that cancer is a complex disease characterized by uncontrolled cell growth and division.
Recognize that cancer development is typically a multistep process involving genetic mutations.
Identify that oncogenes and tumor-suppressor genes play crucial roles in cancer development. Oncogenes promote cell division, while tumor-suppressor genes inhibit it.
Acknowledge that for a cell to become cancerous, it often requires the activation of oncogenes and the inactivation or loss of tumor-suppressor genes.
Conclude that the accumulation of multiple genetic mutations over time is necessary for the full transformation of a normal cell into a cancerous one, aligning with the statement that nearly all cancers are caused by the multistep accumulation of mutations.