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Multiple Choice
Cells are able to distinguish proteins destined for secretion or for segregation to specific intracellular compartments from those that will remain in the cytoplasm because __________.
A
there are two types of ribosomes: one group that synthesizes cytoplasmic proteins only and another type that synthesizes secreted or compartment-specific proteins only
B
proteins destined for secretion or for a specific compartment are all synthesized in the nucleus, whereas cytoplasmic proteins are all synthesized in the cytoplasm
C
each compartment in the cell (the nucleus, lysosome, and so forth) has its own set of ribosomes that synthesize proteins unique to that compartment
D
some proteins, as they begin to be synthesized, contain a signal region that causes the ribosome with its growing polypeptide to attach to the ER and translocate the polypeptide into the lumen (space) of the ER
Verified step by step guidance
1
Understand that proteins are synthesized by ribosomes, which can be free in the cytoplasm or bound to the endoplasmic reticulum (ER).
Recognize that proteins destined for secretion or specific compartments have a signal sequence at the beginning of their synthesis.
This signal sequence is recognized by a signal recognition particle (SRP), which pauses translation and directs the ribosome to the ER membrane.
Once at the ER, the ribosome binds to a receptor, and the growing polypeptide is translocated into the ER lumen.
Inside the ER, the signal sequence is typically cleaved off, and the protein undergoes folding and modifications before being transported to its final destination.