For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop.
Using RB1⁺ for the normal wild-type allele and RB1⁻ for the mutant allele, identify the genotype of a cell in a retinoblastoma tumor.

Question

For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop.
Using RB1⁺ for the normal wild-type allele and RB1⁻ for the mutant allele, identify the genotype of a cell in a retinoblastoma tumor.

Using RB1⁺ for the normal wild-type allele and RB1⁻ for the mutant allele, identify the genotype of a cell in a retinoblastoma tumor.

Accepted Answer

Hello, everyone. Here we have a question that says achondroplasia is a genetic disorder that follows an autosomal dominant inheritance pattern. This condition is caused by mutation in the FGFR three gene which is responsible for making fibroblast growth factor receptor three protein. This protein is involved in the conversion of cartilage into bone. What happens to individuals having a single copy of the FGFR three gene mutation? And our answer choices are a, they are considered carriers. B they will not get affected C, they will have achondroplasia or d the dominant phenotype will not be expressed because it is autosomal dominant. We only need one copy of the mutated gene for the person to have achondroplasia. So the correct answer here is C they will have achondroplasia. Thank you for watching. Bye.

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Key Concepts

Tumor Suppressor Genes and the RB1 Gene

Knudson's Two-Hit Hypothesis

Genotype of Retinoblastoma Tumor Cells