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Ch. 3 - Cell Division and Chromosome Heredity
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooksSanders 3rd EditionCh. 3 - Cell Division and Chromosome HeredityProblem 11b
Chapter 3, Problem 11b

Describe the role of the following structures or proteins in cell division:
Cohesin protein

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1
Understand that cohesin is a protein complex that plays a critical role in cell division by ensuring sister chromatids remain attached to each other after DNA replication.
Learn that cohesin forms a ring-like structure around sister chromatids, physically holding them together to maintain their alignment during the early stages of mitosis and meiosis.
Recognize that cohesin is essential for proper chromosome segregation, as it prevents premature separation of sister chromatids, which could lead to aneuploidy or other genetic errors.
Explore how cohesin is regulated during cell division: it is cleaved by the enzyme separase during anaphase, allowing sister chromatids to separate and move to opposite poles of the cell.
Understand the broader significance of cohesin in maintaining genomic stability and its involvement in certain genetic disorders when its function is impaired.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Cohesin Protein

Cohesin is a protein complex that plays a crucial role in holding sister chromatids together after DNA replication. It forms a ring-like structure that encircles the chromatids, ensuring they remain attached until the appropriate stage of cell division. This attachment is vital for accurate chromosome segregation during mitosis and meiosis, preventing aneuploidy.
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Cell Division

Cell division is the process by which a parent cell divides into two or more daughter cells. It encompasses two main types: mitosis, which results in two genetically identical cells, and meiosis, which produces gametes with half the genetic material. Proper regulation of cell division is essential for growth, development, and tissue repair.
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Chromosome Segregation

Chromosome segregation is the process during cell division where replicated chromosomes are separated and distributed into daughter cells. This process is critical for maintaining genetic stability, as each daughter cell must receive an accurate copy of the genetic material. Cohesin proteins are integral to this process, as they ensure that sister chromatids are held together until the right moment for separation.
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Related Practice
Textbook Question

Alleles A and a are on one pair of autosomes, and alleles B and b are on a separate pair of autosomes. Does crossover between one pair of homologs affect the expected proportions of gamete genotypes? Why or why not? Does crossover between both pairs of chromosomes affect the expected gamete proportions? Why or why not?

Textbook Question

How many Barr bodies are found in a normal human female nucleus? In a normal male nucleus?

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Textbook Question

Describe the role of the following structures or proteins in cell division:

Microtubules

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Textbook Question

Describe the role of the following structures or proteins in cell division:

Kinetochores

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Textbook Question

Describe the role of the following structures or proteins in cell division:

Synaptonemal complex

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Textbook Question

A woman's father has ornithine transcarbamylase deficiency (OTD), an X-linked recessive disorder producing mental deterioration if not properly treated. The woman's mother is homozygous for the wild-type allele.


What is the woman's genotype? (Use D to represent the dominant allele and d to represent the recessive allele.)