A woman, S.R., had a maternal grandfather with hemophilia A (OMIM 306700), an X-linked recessive condition that reduces blood clotting. S.R.'s maternal grandmother and paternal grandparents are free of the condition, as are her partner, his parents, and his grandparents. S.R. has no siblings. She wants to know the chance that a son of hers will have the condition. What is that probability?

Consider the cross AaBbCC × AABbCc.
Use a Punnett square to predict the expected ratio of offspring phenotypes.
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Key Concepts
Punnett Square
Genotype and Phenotype
Mendelian Inheritance
A 40-year-old woman whose father had Huntington disease currently shows no symptoms of the disease. She is newly pregnant with her first child and seeks your best estimate of the chance her child will inherit the disease. What is your estimate and how did you arrive at it? (Hint: See Figure 4.11)
Consider the cross AaBbCC × AABbCc.
How many different gamete genotypes can each organism produce?
Consider the cross AaBbCC × AABbCc.
Use the forked-line method to predict the expected ratio of offspring phenotypes.
If a chi-square test produces a chi-square value of 7.83 with 4 degrees of freedom,
In what interval range does the P value fall?
If a chi-square test produces a chi-square value of 7.83 with 4 degrees of freedom,
Is the result sufficient to reject the chance hypothesis?
