Textbook Question
When the whole-genome shotgun sequence of the Drosophila genome was assembled, it comprised 134 scaffolds made up of 1636 contigs. How can physical gaps be closed?
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Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 16 - Genomics: Genetics from a Whole-Genome PerspectiveProblem 5
Sanders 3rd EditionCh. 16 - Genomics: Genetics from a Whole-Genome PerspectiveProblem 5Chapter 16, Problem 5
How do comparisons between genomes of related species help refine gene annotation?
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Understand that gene annotation is the process of identifying the locations and functions of genes within a genome sequence.
Recognize that comparing genomes of related species allows scientists to identify conserved sequences, which are likely to be functionally important genes or regulatory elements.
Use sequence alignment tools to find regions of similarity between genomes, highlighting potential genes that may have been missed or incorrectly annotated in one species.
Analyze differences and similarities in gene structure, such as exon-intron boundaries, to improve the accuracy of gene models by confirming or adjusting predicted gene features.
Incorporate comparative data to predict gene function based on conserved sequences and evolutionary relationships, thereby refining the annotation with more reliable biological context.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Comparative Genomics
Comparative genomics involves analyzing and comparing the DNA sequences of different species to identify conserved regions. These conserved sequences often indicate important functional elements like genes or regulatory regions, helping to pinpoint gene locations and functions more accurately.
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Genomics Overview
Gene Annotation
Gene annotation is the process of identifying gene locations, structures, and functions within a genome. It involves predicting coding regions, introns, exons, and regulatory elements, often using computational tools and experimental data to assign biological meaning to raw DNA sequences.
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Evolutionary Conservation and Functional Inference
Evolutionary conservation refers to DNA sequences that remain similar across species due to selective pressure. These conserved sequences are likely functionally important, so comparing genomes helps infer gene function and refine annotations by highlighting regions that are biologically significant.
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Related Practice
Textbook Question
When the whole-genome shotgun sequence of the Drosophila genome was assembled, it comprised 134 scaffolds made up of 1636 contigs.
How can sequence gaps be closed?
Textbook Question
How do cDNA sequences facilitate gene annotation? Describe how the use of full-length cDNAs facilitates discovery of alternative splicing.
Textbook Question
You are designing algorithms for the bioinformatic prediction of gene sequences. How might algorithms differ for predicting genes in bacterial versus eukaryotic genomic sequence?
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Textbook Question
You have sequenced a 100-kb region of the Bacillus anthracis genome (the bacterium that causes anthrax) and a 100-kb region from the Gorilla gorilla genome. What differences and similarities might you expect to see in the annotation of the sequences, for example, in the number of genes, gene structure, regulatory sequences, and repetitive DNA?
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Textbook Question
Diseases and conditions on the RUSP list are tested on every newborn infant, and if the baby has one of the conditions, the parents are immediately informed. What kind of information and counseling should be provided to the parents along with the diagnosis?
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