Textbook Question
How do comparisons between genomes of related species help refine gene annotation?
Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 16 - Genomics: Genetics from a Whole-Genome PerspectiveProblem B.7
Sanders 3rd EditionCh. 16 - Genomics: Genetics from a Whole-Genome PerspectiveProblem B.7Chapter 16, Problem B.7
Diseases and conditions on the RUSP list are tested on every newborn infant, and if the baby has one of the conditions, the parents are immediately informed. What kind of information and counseling should be provided to the parents along with the diagnosis?
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Explain the nature of the diagnosed condition, including its genetic basis, mode of inheritance, and how it affects the infant's health and development.
Discuss the potential treatments, management options, and prognosis to help parents understand what to expect and how to care for their child.
Provide information about the likelihood of recurrence in future pregnancies, including the genetic risks and options for genetic counseling or testing for the parents and family members.
Offer emotional support resources, such as connecting parents with support groups, counseling services, and healthcare professionals specialized in the condition.
Ensure parents understand the importance of follow-up care and monitoring, and provide clear guidance on next steps, including referrals to specialists or early intervention programs.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Newborn Screening and RUSP
The Recommended Uniform Screening Panel (RUSP) is a list of genetic, metabolic, and other conditions screened in newborns to enable early detection and treatment. Understanding the purpose and scope of RUSP helps explain why early diagnosis is critical for preventing severe health issues or developmental delays.
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Genetic Counseling
Genetic counseling involves providing parents with clear information about the diagnosed condition, inheritance patterns, prognosis, and available treatments. It supports informed decision-making and emotional coping by addressing parents’ questions and concerns about the child’s health and future.
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Psychosocial Support and Communication
Effective communication includes delivering the diagnosis with sensitivity, offering emotional support, and connecting families to resources such as support groups or specialists. This helps parents manage stress, understand the implications, and plan for ongoing care and interventions.
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Related Practice
Textbook Question
You are designing algorithms for the bioinformatic prediction of gene sequences. How might algorithms differ for predicting genes in bacterial versus eukaryotic genomic sequence?
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Textbook Question
You have sequenced a 100-kb region of the Bacillus anthracis genome (the bacterium that causes anthrax) and a 100-kb region from the Gorilla gorilla genome. What differences and similarities might you expect to see in the annotation of the sequences, for example, in the number of genes, gene structure, regulatory sequences, and repetitive DNA?
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Textbook Question
You have just obtained 100 kb of genomic sequence from an as-yet-unsequenced mammalian genome. What are three methods you might use to identify potential genes in the 100 kb? What are the advantages and limitations of each method?
Textbook Question
The human genome contains a large number of pseudogenes. How would you distinguish whether a particular sequence encodes a gene or a pseudogene? How do pseudogenes arise?
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Textbook Question
Based on the tree of life in the following figure (Figure 16.12), would you expect human proteins to be more similar to fungal proteins or to plant proteins? Would you expect plant proteins to be more similar to fungal proteins or to human proteins?