Textbook Question
What kind of information will be made available by The Cancer Genome Atlas (TCGA)? What sort of role do you think TCGA information will play in cancer diagnosis and cancer treatment in the future?
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Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.11d
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.11dChapter 14, Problem C.11d
Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. What are the approximate rates of cancer that develop in people carrying a mutation of one of these genes?
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Understand that Lynch syndrome is a hereditary condition caused by mutations in mismatch repair genes, which significantly increase the risk of certain cancers, especially colorectal and endometrial cancers.
Navigate to the NCBI OMIM website and enter 'Lynch syndrome' in the search box to find detailed genetic and clinical information about the syndrome.
Select the entry '#120435—Lynch Syndrome' to access comprehensive data, including gene mutations involved and associated cancer risks.
Locate the section within the OMIM entry that discusses cancer risks or penetrance, which typically provides approximate percentages or rates of cancer development in mutation carriers.
Interpret the data by noting the approximate lifetime risk percentages for different types of cancers (e.g., colorectal, endometrial) in individuals with Lynch syndrome gene mutations, understanding that these rates reflect increased susceptibility compared to the general population.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lynch Syndrome and Its Genetic Basis
Lynch syndrome is an inherited disorder caused by mutations in DNA mismatch repair genes, such as MLH1, MSH2, MSH6, and PMS2. These mutations increase the risk of developing certain cancers, especially colorectal and endometrial cancers, by impairing the cell's ability to correct DNA replication errors.
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Cancer Penetrance in Mutation Carriers
Penetrance refers to the proportion of individuals with a specific genetic mutation who exhibit the associated disease. In Lynch syndrome, penetrance is expressed as the approximate lifetime risk or rate of developing cancer among mutation carriers, which varies depending on the gene mutated and other factors.
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Using OMIM Database for Genetic Information
OMIM (Online Mendelian Inheritance in Man) is a comprehensive database cataloging human genes and genetic disorders. It provides detailed information on gene mutations, associated phenotypes, and epidemiological data, such as cancer risk rates in Lynch syndrome, enabling researchers and students to access reliable genetic information.
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Related Practice
Textbook Question
You have identified a gene encoding the protein involved in the rate-limiting step in vitamin E biosynthesis. How would you create a transgenic plant producing large quantities of vitamin E in its seeds?
Textbook Question
Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. What genes are most commonly mutated in Lynch syndrome?
Textbook Question
Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. There are two types of Lynch syndrome. What are they?
Textbook Question
Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions. Provide a brief summary of the normal functions of the protein products of these genes.
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Textbook Question
You have identified a recessive mutation that alters bristle patterning in Drosophila and have used recombinant DNA technology to identify a genomic clone that you believe harbors the gene. How would you demonstrate that your gene is on the genomic clone?