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Ch. 9 - Cellular Respiration and Fermentation
Freeman - Biological Science 8th Edition
Freeman8th EditionBiological ScienceISBN: 9780138276263Not the one you use?Change textbook
All textbooksFreeman 8th EditionCh. 9 - Cellular Respiration and FermentationProblem 1
Chapter 9, Problem 1

Where does the citric acid cycle occur in eukaryotes? a. in the cytosol of cells b. in the intermembrane space of mitochondria c. in the inner membrane of mitochondria d. in the matrix of mitochondria

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1
Identify the location where the citric acid cycle occurs. The citric acid cycle, also known as the Krebs cycle, is a key metabolic pathway that generates energy through the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide.
Understand the structure of mitochondria. Mitochondria have an outer membrane, an inner membrane, and two internal compartments: the intermembrane space and the matrix.
Recall that the citric acid cycle involves enzymes that catalyze the reactions of the cycle. These enzymes are located in a specific part of the mitochondria.
Eliminate incorrect options: The citric acid cycle does not occur in the cytosol (option a), the intermembrane space (option b), or the inner membrane (option c) of mitochondria.
Conclude that the correct answer is d. The citric acid cycle takes place in the matrix of mitochondria, where the necessary enzymes and conditions are present.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle, is a series of chemical reactions used by all aerobic organisms to generate energy. It plays a crucial role in cellular respiration by oxidizing acetyl-CoA to produce ATP, NADH, and FADH2, which are essential for energy production.
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Mitochondria

Mitochondria are membrane-bound organelles found in eukaryotic cells, often referred to as the 'powerhouses' of the cell. They are responsible for producing ATP through oxidative phosphorylation and are the site of the citric acid cycle, specifically within their inner compartments.
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Mitochondrial Matrix

The mitochondrial matrix is the innermost compartment of the mitochondria, enclosed by the inner membrane. It contains enzymes necessary for the citric acid cycle, as well as mitochondrial DNA and ribosomes, facilitating the production of proteins required for mitochondrial function.
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Related Practice
Textbook Question

What does the chemiosmotic hypothesis claim?

a. ATP is generated using phosphates taken from intermediates in the electron transport chain.

b. ATP is generated using a phosphate gradient produced by glycolysis and the citric acid cycle.

c. ATP is generated using a proton-motive force that is produced by the electron transport chain.

d. Water is generated using electrons taken from NADH and FADH2 and transported through the electron transport chain.

Textbook Question

After glucose is fully oxidized by glycolysis, pyruvate processing, and the citric acid cycle, where is most of its energy stored?

Textbook Question

Which of the following correctly describe the fermentation pathway? Select True or False for each statement.

T/FIt includes a reaction that oxidizes NADH to NAD+.

T/FIt synthesizes ATP by substrate-level phosphorylation.

T/FIt includes a reaction that reduces NAD+ to NADH.

T/FIt synthesizes electron acceptors, so that cellular respiration can continue.

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