Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart2h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

23. The Digestive System

The Stomach

Anatomy & Physiology

23. The Digestive System

The Stomach

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Multiple Choice

Proton Pump Inhibitors (or PPIs) are some of the widely used drugs in the world and are prescribed for chronic heartburn/acid reflux. They work by inhibiting the movement of H⁺ ions across the membrane into the gastric juice, thereby lowering the concentration of HCl. As described, which cell of the gastric glands would you expect PPIs to affect?

Chief cells.

Enteroendocrine cells.

Mucous neck cells.

Parietal cells.

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Verified step by step guidance

Begin by understanding the role of each cell type in the gastric glands. Parietal cells are responsible for secreting hydrochloric acid (HCl) into the stomach, which is crucial for digestion.

Recognize that Proton Pump Inhibitors (PPIs) target the proton pumps located in the parietal cells. These pumps are responsible for the secretion of hydrogen ions (H+) into the gastric lumen, which combine with chloride ions (Cl-) to form hydrochloric acid (HCl).

Consider the mechanism of PPIs: they inhibit the proton pumps, reducing the movement of H+ ions across the cell membrane into the gastric juice. This action decreases the acidity of the stomach by lowering the concentration of HCl.

Evaluate the impact of PPIs on the gastric environment. By inhibiting the parietal cells' ability to produce HCl, PPIs effectively reduce stomach acidity, which helps alleviate symptoms of acid reflux and heartburn.

Conclude that PPIs specifically affect parietal cells due to their role in acid secretion, while other cells like chief cells, enteroendocrine cells, and mucous neck cells have different functions unrelated to acid production.