33. The Organic Chemistry of Metabolic Pathways

Identify the mechanism for each of the following reactions as NAS, E1cB, or S_N2.

a) ____ Dehydration of 2-phosphoglycerate to produce phosphoenolpyruvate.

b) ____ Conversion of 1,3-bisphosphoglycerate into 3-phosphoglycerate.

c) ____ Conversion of glucose into glucose-6-phosphate.

d) ____ Conversion of 3-phosphoglycerate into 2-phosphoglycerate.

If the P atom in 3-phosphoglycerate is labelled with phosphorous-32, where does the label end up after it is isomerized to 2-phosphoglycerate in step 8 of glycolysis?