Textbook Question
The flow diagram identifies relationships between bacterial strains in various F factor states. For each of the four arrows in the diagram, provide a description of the events involved in the transition.
Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
Not the one you use?Change textbookSelect a different textbook
Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooks
Sanders 3rd EditionCh. 6 - Genetic Analysis and Mapping in Bacteria and BacteriophagesProblem A.2d
Sanders 3rd EditionCh. 6 - Genetic Analysis and Mapping in Bacteria and BacteriophagesProblem A.2dChapter 6, Problem A.2d
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Go to the 'Molecular Genetics' section and describe the most common mutation of the CF gene.
Verified step by step guidance1
Go to the OMIM website (https://omim.org) and enter 'Cystic Fibrosis' or 'CF gene' in the search bar to find the relevant entry for the CFTR gene, which is responsible for cystic fibrosis.
Navigate to the 'Molecular Genetics' section of the CFTR gene entry to find detailed information about mutations associated with cystic fibrosis.
Identify the most common mutation listed in this section. Typically, this is the ΔF508 (also written as p.Phe508del) mutation, which involves the deletion of a specific amino acid in the CFTR protein.
Understand that the ΔF508 mutation results in the loss of phenylalanine at position 508 in the CFTR protein, which affects the protein's folding and function, leading to the symptoms of cystic fibrosis.
Summarize the mutation by describing its type (deletion), its effect on the protein, and why it is the most common mutation causing cystic fibrosis.
Verified video answer for a similar problem:
This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
1mWas this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene
The CFTR gene encodes a protein that functions as a chloride channel in epithelial cells, crucial for maintaining fluid balance in organs like the lungs and pancreas. Mutations in this gene disrupt ion transport, leading to cystic fibrosis symptoms such as thick mucus buildup and respiratory issues.
Recommended video:
Guided course
04:08
Pleiotropy
Common Mutations in the CFTR Gene
The most common mutation in the CFTR gene is the ΔF508 deletion, which removes a phenylalanine at position 508. This mutation causes misfolding of the CFTR protein, preventing it from reaching the cell surface and impairing chloride ion transport, which is central to cystic fibrosis pathology.
Recommended video:
Guided course
04:46Cancer Mutations
Using the OMIM Database for Genetic Research
OMIM is an online resource that catalogs human genes and genetic disorders, providing detailed molecular genetics information. It is used to identify gene mutations, understand their effects, and explore genotype-phenotype relationships, aiding in research and clinical diagnosis.
Recommended video:
Guided course
11:35History of Genetics
Related Practice
Textbook Question
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Go to the 'Population Genetics' section discussing the TSD gene. In a few sentences, summarize the human population in which TSD is most frequently found and give the approximate frequency of heterozygous carriers for the TSD mutation in North American Jews.
Textbook Question
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up Tay–Sachs disease (TSD), OMIM number 272800, and give the name and abbreviation of the affected gene and the chromosome location of the gene.
Textbook Question
Go online to the Online Mendelian Inheritance of Man (OMIM) website. Look up the following genetic conditions and answer the questions posed about them.
Look up cystic fibrosis (CF), OMIM 602421, and give the gene name and abbreviation and the chromosome location of the gene.
Textbook Question
Conjugation between an Hfr cell and an F⁻ cell does not usually result in conversion of exconjugants to the donor state. Occasionally, however, the result of this conjugation is two Hfr cells. Explain how this occurs.
Textbook Question
A couple comes into your genetic counseling practice with a question about the chance a future child of theirs might have a genetic disease. Three or four men in the woman's family, including her father, had a condition that might be genetic. Although her father is still alive, she has had little contact with him for much of her life and cannot describe or name the condition. Her partner is a healthy man whose family has no history indicating the presence of a genetic condition. To provide more information about this possible genetic condition for the couple, what is the first step you recommend?
4
views