Textbook Question
What are the advantages and disadvantages of using GFP versus lacZ as a reporter gene in mice, C. elegans, and Drosophila?
Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.1c
Sanders 3rd EditionCh. 14 - Analysis of Gene Function via Forward Genetics and Reverse GeneticsProblem C.1cChapter 14, Problem C.1c
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
p53(Li–Fraumeni syndrome)
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Understand that the p53 gene is a tumor suppressor gene, which means its normal function is to regulate the cell cycle and prevent uncontrolled cell division.
Recognize that p53 plays a critical role in DNA damage response by either repairing damaged DNA or initiating apoptosis (programmed cell death) if the damage is irreparable.
Note that mutations in p53 can lead to loss of its tumor suppressor function, allowing cells with damaged DNA to proliferate, which contributes to cancer development.
Connect the mutation of p53 with Li–Fraumeni syndrome, a hereditary disorder characterized by a predisposition to multiple types of cancer due to defective p53 function.
Summarize that the normal function of p53 is to maintain genomic stability by controlling cell cycle checkpoints, DNA repair, and apoptosis, thereby preventing tumor formation.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Tumor Suppressor Genes
Tumor suppressor genes produce proteins that regulate cell growth and division, preventing uncontrolled proliferation. When these genes, like p53, are mutated, their protective function is lost, leading to increased cancer risk. They act as cellular 'brakes' to stop tumor development.
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Function of p53 Gene
The p53 gene encodes a protein that monitors DNA integrity and can induce cell cycle arrest, DNA repair, or apoptosis in response to damage. It is often called the 'guardian of the genome' because it prevents propagation of mutated cells, thereby suppressing tumor formation.
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Li–Fraumeni Syndrome
Li–Fraumeni syndrome is a hereditary disorder caused by germline mutations in the p53 gene, leading to a high predisposition to various cancers at a young age. Understanding this syndrome highlights the critical role of p53 in cancer prevention and genetic inheritance patterns.
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Related Practice
Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
Which of these genes would you classify as a proto-oncogene and which as a tumor suppressor gene? Explain your categorization for each gene.
Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
RB1(retinoblastoma)
3
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Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
c-MYC(Burkitt lymphoma)
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Textbook Question
Identify the normal functions of the following genes whose mutations are associated with the development of cancer.
APC(familial adenomatous polyposis)
5
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