Textbook Question
Nitrous acid and 5-bromodeoxyuracil (BrdU) alter DNA by different mechanisms. What type of mutation does each compound produce?

Sanders 3rd Edition
Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination
Problem 1
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Nitrous acid and 5-bromodeoxyuracil (BrdU) alter DNA by different mechanisms. What type of mutation does each compound produce?
What is the difference between a transition mutation and a transversion mutation?
For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop. Define the 'two-hit hypothesis' for retinoblastoma.