Multiple Choice
DNA replication occurs differently at telomeres.
16. Cell Division
DNA Replication
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Only the lagging strand uses telomerase to replicate the ends of the telomeres?
A
True
B
False
Verified step by step guidance1
Understand the role of telomerase: Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres, to prevent them from shortening during DNA replication.
Differentiate between leading and lagging strands: During DNA replication, the leading strand is synthesized continuously, while the lagging strand is synthesized in short segments called Okazaki fragments.
Recognize the problem of end replication: The lagging strand faces a problem at the very end of the chromosome because the RNA primer used for the last Okazaki fragment cannot be replaced with DNA, leading to a gradual shortening of the chromosome.
Identify the role of telomerase in solving this problem: Telomerase extends the 3' end of the lagging strand template, allowing for the complete replication of the chromosome ends by providing a template for the final Okazaki fragment.
Conclude which strand uses telomerase: Since telomerase specifically addresses the issue of incomplete replication on the lagging strand, it is primarily associated with the replication of the lagging strand ends.
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