Table of contents

1. Introduction to Anatomy & Physiology5h 43m
2. Cell Chemistry & Cell Components12h 36m
3. Energy & Cell Processes10h 6m
4. Tissues & Histology10h 3m
5. Integumentary System2h 20m
6. Bones & Skeletal Tissue2h 16m
7. The Skeletal System2h 35m
8. Joints2h 17m
9. Muscle Tissue2h 33m
10. Muscles1h 11m
11. Nervous Tissue and Nervous System1h 35m
12. The Central Nervous System1h 6m
- Introduction to the Central Nervous System
  18m
- The Cerebrum
  48m
13. The Peripheral Nervous System1h 26m
14. The Autonomic Nervous System1h 38m
15. The Special Senses2h 41m
16. The Endocrine System2h 48m
17. The Blood3h 22m
18. The Heart2h 42m
19. The Blood Vessels3h 35m
20. The Lymphatic System3h 16m
21. The Immune System14h 37m
22. The Respiratory System3h 20m
23. The Digestive System2h 5m
24. Metabolism and Nutrition4h 0m
25. The Urinary System2h 39m
26. Fluid and Electrolyte Balance, Acid Base Balance37m
27. The Reproductive System2h 5m
28. Human Development1h 21m
29. Heredity3h 32m

9. Muscle Tissue

Sliding Filament Theory and the Sacromere

Anatomy & Physiology

9. Muscle Tissue

Sliding Filament Theory and the Sacromere

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Multiple Choice

Myosin storage myopathy is a rare congenital condition where some of the myosin folds incorrectly in certain skeletal muscles creating clumps. Individuals with this condition exhibit muscle weakness and may be delayed in learning to walk as infants. What changes would you expect to see if you were to examine the sarcomere of an individual with this condition?

The thick filament would form protein clumps.

The thin filament would form protein clumps.

The titin would form protein clumps.

The fascicle proteins would form clumps.

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Verified step by step guidance

Understand the structure of a sarcomere: A sarcomere is the basic contractile unit of muscle fiber, composed of thick filaments (myosin) and thin filaments (actin), along with other proteins like titin.

Identify the role of myosin: Myosin is a motor protein that forms the thick filament in the sarcomere and is crucial for muscle contraction.

Consider the impact of myosin misfolding: In myosin storage myopathy, misfolded myosin can lead to the formation of clumps, disrupting the normal structure and function of the sarcomere.

Analyze the expected changes in the sarcomere: Due to the misfolding of myosin, you would expect to see clumps of thick filaments within the sarcomere, affecting muscle contraction.

Evaluate the options: Given the condition affects myosin, the correct expectation is that the thick filament would form protein clumps, rather than the thin filament, titin, or fascicle proteins.