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Multiple Choice
Enzyme activity is affected by pH because __________.
A
most substrates do not function well at high or low pH
B
low pH will denature all enzymes
C
changes in pH can cause loss of cofactors from the enzyme
D
the binding of hydrogen ions to the enzyme absorbs energy and thus there may not be enough energy to overcome the activation energy barrier
E
high or low pH may disrupt hydrogen bonding or ionic interactions and thus change the shape of the active site
Verified step by step guidance
1
Understand that enzymes are proteins that catalyze biochemical reactions by lowering the activation energy required for the reaction to proceed.
Recognize that the active site of an enzyme is where the substrate binds, and this site is highly specific to the substrate's shape and chemical properties.
Learn that enzymes have an optimal pH range where they function most effectively. Deviations from this optimal pH can affect enzyme activity.
Explore how changes in pH can alter the ionization state of amino acids in the enzyme, particularly those involved in hydrogen bonding and ionic interactions, which are crucial for maintaining the enzyme's structure.
Realize that when the enzyme's structure is altered due to changes in pH, the shape of the active site may change, potentially reducing the enzyme's ability to bind substrates and catalyze reactions effectively.