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Multiple Choice
Osteonecrosis is a condition where blood flow to bones is cut off resulting in tissue death. Which of the following would you expect to be most directly affected by the loss of blood flow?
A
The inorganic matrix.
B
Collagen fibers.
C
Osteocytes.
D
A-C are correct.
Verified step by step guidance
1
Understand the role of blood flow in bone health: Blood flow is crucial for delivering nutrients and oxygen to bone cells, including osteocytes, which are responsible for maintaining bone tissue.
Identify the components of bone tissue: Bone tissue consists of an inorganic matrix (primarily calcium phosphate), collagen fibers, and osteocytes. Each component has a different role in bone structure and function.
Analyze the impact of blood flow loss: Osteocytes, being living cells, require a constant supply of nutrients and oxygen, which are delivered via blood flow. The inorganic matrix and collagen fibers are structural components and do not require direct blood supply for their maintenance.
Consider the consequences of osteonecrosis: When blood flow is cut off, osteocytes are most directly affected because they rely on blood for survival. Without blood flow, these cells can die, leading to tissue death and compromised bone integrity.
Conclude which component is most affected: Given the reliance of osteocytes on blood supply, they are the most directly affected by the loss of blood flow in osteonecrosis, compared to the inorganic matrix and collagen fibers.